Comments on: PILLS TO KEEP YOU WARM (Nov, 1957) http://blog.modernmechanix.com/2008/09/07/pills-to-keep-you-warm/ Yesterday's tomorrow, today. Fri, 10 Feb 2012 17:21:58 +0000 hourly 1 http://wordpress.org/?v=3.1.4 By: Pinky http://blog.modernmechanix.com/2008/09/07/pills-to-keep-you-warm/comment-page-1/#comment-1068951 Pinky Mon, 15 Jun 2009 11:43:35 +0000 http://blog.modernmechanix.com/?p=5351#comment-1068951 Glycine disrupts the energy-generating process within cells, causing potential energy to be released as heat instead of ATP, which is the fuel that powers cells. This mean the body (mainly fat tissue) actually produces heat to keep warm. It is not a drug that blocks the feeling of cold. Of course this requires energy; use of glycine in a survival situation would require energy supplementation in a condensed and easily assimilated form. Glycine disrupts the energy-generating process within cells, causing potential energy to be released as heat instead of ATP, which is the fuel that powers cells. This mean the body (mainly fat tissue) actually produces heat to keep warm. It is not a drug that blocks the feeling of cold. Of course this requires energy; use of glycine in a survival situation would require energy supplementation in a condensed and easily assimilated form.

]]> By: Charlie http://blog.modernmechanix.com/2008/09/07/pills-to-keep-you-warm/comment-page-1/#comment-1060320 Charlie Sun, 07 Sep 2008 18:20:53 +0000 http://blog.modernmechanix.com/?p=5351#comment-1060320 fluffy: True, you would loose a lot of heat to people trying to pet the snow. fluffy: True, you would loose a lot of heat to people trying to pet the snow.

]]> By: fluffy http://blog.modernmechanix.com/2008/09/07/pills-to-keep-you-warm/comment-page-1/#comment-1060318 fluffy Sun, 07 Sep 2008 17:21:45 +0000 http://blog.modernmechanix.com/?p=5351#comment-1060318 Now one pill which COULD work is MDMA cut with amphetamines. Of course, there's some other fun side effects that might not make it quite appropriate for that circumstance. Now one pill which COULD work is MDMA cut with amphetamines. Of course, there’s some other fun side effects that might not make it quite appropriate for that circumstance.

]]> By: Firebrand38 http://blog.modernmechanix.com/2008/09/07/pills-to-keep-you-warm/comment-page-1/#comment-1060313 Firebrand38 Sun, 07 Sep 2008 16:01:47 +0000 http://blog.modernmechanix.com/?p=5351#comment-1060313 The abstract from the 1961 Final Report explains that it didn't work: Glycine (amino-acetic acid) and other calorigenic, dietary adjuncts have received considerable attention recently and have been reported to modify whole body responses to cold exposure and hypothermia. In addition to any pharmacological action, the potential value of glycine and similar materials lies in their ability to provide ADDITIONAL CALORIES TO THE COOLING ORGANISM VIA THE MECHANISM OF SPECIFIC DYNAMIC ACTION. Thirty grams of glycine were administered orally to five volunteer, male subjects who were subsequently exposed nude to an environment of 10 C. Measurements of rectal and extremity surface temperatures and whole body metabolic rates failed to show any statistically significant effects that could be attributed to the influence of glycine, as compared to glucose control measurements, throughout a 1-hour cold exposure. At this level of cold stress and drug dosage, glycine could not be seen to affect cold elicited, physiological responses and its values in mitigating human cold exposure is questioned. Reports of glycine effects for more severe cold stresses or during deep hypothermia may possibly be attributed to a more precipitous rate of heat loss, to a greater degree of cooling, or to other factors. The abstract from the 1961 Final Report explains that it didn’t work:

Glycine (amino-acetic acid) and other calorigenic, dietary adjuncts have received considerable attention recently and have been reported to modify whole body responses to cold exposure and hypothermia. In addition to any pharmacological action, the potential value of glycine and similar materials lies in their ability to provide ADDITIONAL CALORIES TO THE COOLING ORGANISM VIA THE MECHANISM OF SPECIFIC DYNAMIC ACTION. Thirty grams of glycine were administered orally to five volunteer, male subjects who were subsequently exposed nude to an environment of 10 C. Measurements of rectal and extremity surface temperatures and whole body metabolic rates failed to show any statistically significant effects that could be attributed to the influence of glycine, as compared to glucose control measurements, throughout a 1-hour cold exposure. At this level of cold stress and drug dosage, glycine could not be seen to affect cold elicited, physiological responses and its values in mitigating human cold exposure is questioned. Reports of glycine effects for more severe cold stresses or during deep hypothermia may possibly be attributed to a more precipitous rate of heat loss, to a greater degree of cooling, or to other factors.

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